Hung-Pin Peng, Ph.D.

彭 洪 斌

abdev-suite · 2026

ISMBLab · maintainer

NGS · GPU

OMOP · OHDSI

2026–2028

2026–2027

2020–2021

2024

2024

2024

  1. Yeh JT†, Peng HP†, Hung FH, Hung CF, Hsieh LL, Yang AS, Wang YA*. Mismatch repair (MMR) gene mutation carriers have favorable outcome in colorectal and endometrial cancer: a prospective cohort study. Cancers. 2024;16(13):2342. doi:10.3390/cancers16132342
  2. Peng HP, Hsu HJ, Yu CM, Hung FH, Tung CP, Huang YC, Chen CY, Tsai PH, Yang AS*. Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens. Scientific Reports. 2022;12(1):12555. doi:10.1038/s41598-022-16841-9
  3. Peng HP, Lee KH, Jian JW, Yang AS*. Origins of specificity and affinity in antibody–protein interactions. Proceedings of the National Academy of Sciences USA. 2014;111(26):E2656–E2665. doi:10.1073/pnas.1401131111
  4. Yu CM†, Peng HP†, Chen IC, Lee YC, Chen JB, Tsai KC, Chen CT, Chang JY, Yang EW, Hsu PC, Jian JW, Hsu HJ, Chang HJ, Hsu WL, Huang KF, Ma AC, Yang AS*. Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface. PLoS ONE. 2012;7(3):e33340. doi:10.1371/journal.pone.0033340
  5. Peng HP, Yang AS*. Modeling protein loops with knowledge-based prediction of sequence-structure alignment. Bioinformatics. 2007;23(21):2836–2842. doi:10.1093/bioinformatics/btm456

  1. Cheng CG†, Chen YH†, Chien WC, Chiu HW, Hung FH, Peng HP, Chung CH, Cheng CA*. Increased risk of injury in patients with Fabry disease: a nationwide population-based cohort study in Taiwan. International Journal of Medical Sciences. 2026;23(7):2376–2386. doi:10.7150/ijms.120352
  2. Cheng CG, Chen CF, Chien WC, Wu CC, Chiu HW, Hung FH, Peng HP, Chung CH, Cheng CA*. Increased risk of recurrent ischemic stroke in male patients taking medications for benign prostatic hyperplasia. Life. 2026;16(2):311. doi:10.3390/life16020311
  3. Lu RM, Chiang HL, Yuan JPY, Wang HH, Chen CY, Panda SS, Liang KH, Peng HP, Ko SH, Hsu HJ, Kumari M, Su YJ, Tse YT, Chou NL, Wu HC*. Technological advancements in antibody-based therapeutics for treatment of diseases. Journal of Biomedical Science. 2025;32(1):98. doi:10.1186/s12929-025-01190-2
  4. Hung FH, Peng HP, Hung CF, Hsieh LL, Yang AS, Wang YA*. Performance evaluation of predictive models for detecting MMR gene mutations associated with Lynch syndrome in cancer patients in a Chinese cohort in Taiwan. International Journal of Cancer. 2024;155(12):2201–2210. doi:10.1002/ijc.35106
  5. Fang SY, Hsieh LL, Hung CF, Hung FH, Peng HP, Yang AS, Wang YA*. Attitude towards hereditary cancer risk management among women with cancer in Taiwan. Supportive Care in Cancer. 2022;30(4):3625–3632. doi:10.1007/s00520-021-06742-4
  6. Hsu HJ, Tung CP, Yu CM, Chen CY, Chen HS, Huang YC, Tsai PH, Lin SI, Peng HP, Chiu YK, Tsou YL, Kuo WY, Jian JW, Hung FH, Hsieh CY, Hsiao M, Chuang SSH, Shen CN, Wang YA, Yang AS*. Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries. Scientific Reports. 2021;11(1):15430. doi:10.1038/s41598-021-94902-1
  7. Yu CM, Chen IC, Tung CP, Peng HP, Jian JW, Chiu YK, Tsou YL, Chen HS, Huang YJ, Hsiao WWW, Wang YA, Yang AS*. A panel of anti-influenza virus nucleoprotein antibodies selected from phage-displayed synthetic antibody libraries with rapid diagnostic capability to distinguish diverse influenza virus subtypes. Scientific Reports. 2020;10(1):13318. doi:10.1038/s41598-020-70135-6
  8. Jian JW, Chen HS, Chiu YK, Peng HP, Tung CP, Chen IC, Yu CM, Tsou YL, Kuo WY, Hsu HJ, Yang AS*. Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities. mAbs. 2019;11(2):373–387. doi:10.1080/19420862.2018.1550320
  9. Kuo WY, Hsu HJ, Wu CY, Chen HS, Chou YC, Tsou YL, Peng HP, Jian JW, Yu CM, Chiu YK, Chen IC, Tung CP, Hsiao M, Lin CL, Wang YA, Wang AHJ, Yang AS*. Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. mAbs. 2019;11(1):153–165. doi:10.1080/19420862.2018.1541370
  10. Hung FH, Wang YA, Jian JW, Peng HP, Hsieh LL, Hung CF, Yang MM, Yang AS*. Evaluating BRCA mutation risk predictive models in a Chinese cohort in Taiwan. Scientific Reports. 2019;9(1):10229. doi:10.1038/s41598-019-46707-6
  11. Wang YA, Jian JW, Hung CF, Peng HP, Yang CF, Cheng HCS, Yang AS*. Germline breast cancer susceptibility gene mutations and breast cancer outcomes. BMC Cancer. 2018;18(1):315. doi:10.1186/s12885-018-4229-5
  12. Jian JW, Elumalai P, Pitti T, Wu CY, Tsai KC, Chang JY, Peng HP, Yang AS*. Predicting ligand binding sites on protein surfaces by 3-dimensional probability density distributions of interacting atoms. PLoS ONE. 2016;11(8):e0160315. doi:10.1371/journal.pone.0160315
  13. Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, … Peng HP (author 31 of 52), Yang AS, … Mascola JR, Kwong PD*. Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell. 2015;161(6):1280–1292. doi:10.1016/j.cell.2015.05.007 Collaboration with the NIH Vaccine Research Center.
  14. Tung CP, Chen IC, Yu CM, Peng HP, Jian JW, Ma SH, Lee YC, Jan JT, Yang AS*. Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries. Scientific Reports. 2015;5:15053. doi:10.1038/srep15053
  15. Chen HS, Hou SC, Jian JW, Goh KS, Shen ST, Lee YC, You JJ, Peng HP, Kuo WC, Chen ST, Peng MC, Wang AHJ, Yu CM, Chen IC, Tung CP, Chen TH, Chiu KP, Ma C, Wu CY, Lin SW, Yang AS*. Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens. Scientific Reports. 2015;5:12411. doi:10.1038/srep12411
  16. Mahalingam R, Peng HP, Yang AS*. Prediction of fatty acid-binding residues on protein surfaces with three-dimensional probability distributions of interacting atoms. Biophysical Chemistry. 2014;192:10–19. doi:10.1016/j.bpc.2014.05.002
  17. Mahalingam R, Peng HP, Yang AS*. Prediction of FMN-binding residues with three-dimensional probability distributions of interacting atoms on protein surfaces. Journal of Theoretical Biology. 2014;343:154–161. doi:10.1016/j.jtbi.2013.10.020
  18. Hsu HJ, Lee KH, Jian JW, Chang HJ, Yu CM, Lee YC, Chen IC, Peng HP, Wu CY, Huang YF, Shao CY, Chiu KP, Yang AS*. Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments. Structure. 2014;22(1):22–34. doi:10.1016/j.str.2013.10.006
  19. Chang HJ, Jian JW, Hsu HJ, Lee YC, Chen HS, You JJ, Hou SC, Shao CY, Chen YJ, Chiu KP, Peng HP, Lee KH, Yang AS*. Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments. Structure. 2014;22(1):9–21. doi:10.1016/j.str.2013.10.005
  20. Tsai KC, Jian JW, Yang EW, Hsu PC, Peng HP, Chen CT, Chen JB, Chang JY, Hsu WL, Yang AS*. Prediction of carbohydrate binding sites on protein surfaces with 3-dimensional probability density distributions of interacting atoms. PLoS ONE. 2012;7(7):e40846. doi:10.1371/journal.pone.0040846
  21. Lin TL, Yang FL, Yang AS, Peng HP, Li TL, Tsai MD, Wu SH, Wang JT*. Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide. PLoS ONE. 2012;7(10):e46783. doi:10.1371/journal.pone.0046783
  22. Chen CT, Peng HP, Jian JW, Tsai KC, Chang JY, Yang EW, Chen JB, Ho SY, Hsu WL, Yang AS*. Protein-protein interaction site predictions with three-dimensional probability distributions of interacting atoms on protein surfaces. PLoS ONE. 2012;7(6):e37706. doi:10.1371/journal.pone.0037706
  23. Chang HJ, Hsu HJ, Chang CF, Peng HP, Sun YK, Yu HM, Shih HC, Song CY, Lin YT, Chen CC*. Molecular evolution of cystine-stabilized miniproteins as stable proteinaceous binders. Structure. 2009;17(4):620–631. doi:10.1016/j.str.2009.01.011
  24. Shao YM, Yang WB, Peng HP, Hsu MF, Tsai KC, Kuo TH, Wang AHJ, Liang PH, Lin CH, Yang AS, Wong CH*. Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors. ChemBioChem. 2007;8(14):1654–1657. doi:10.1002/cbic.200700254
  25. Hsu HJ, Chang HJ, Peng HP, Huang SS, Lin MY, Yang AS*. Assessing computational amino acid β-turn propensities with a phage-displayed combinatorial library and directed evolution. Structure. 2006;14(10):1499–1510. doi:10.1016/j.str.2006.08.006

  1. Peng HP, Yang AS*. Computational analysis of antibody paratopes for antibody sequences in antibody libraries. In: Computer-Aided Antibody Design. Methods in Molecular Biology, vol 2552, ch 24. New York: Humana Press; 2023. p. 437–445. doi:10.1007/978-1-0716-2609-2_24

2025–
2023–2025
2014–2022
2007–2014
2025
2026